Endocrine Abstracts

Cortistatin (CST), a neuropeptide with high structural homology with somatostatin (SS), binds all SS receptor (SS-R) subtypes but, unlike SS, also shows high binding affinity to ghrelin (GRLN) receptor (GRLN-R). In humans CST exerts the same endocrine activities of SS, suggesting that the activation of the SS-R might mask the potential interaction with the GRLN system.CST-8, a synthetic CST-analogue devoid of any binding affinity to SS-R but capable to b...